BME 590 Microfluidic Device Design - Fall 2017

Lectures: 10:15–11:30 TR, 4155 Engineering Building III
Office: Glenn Walker, 4206C EB3,
Office hours: Drop in or check my calendar and email me for an appointment Labs: Room 4205 Engineering Building III

Course Objectives

By the end of the course, students will be able to:


No textbook is assigned for this course. The texts listed below provide a good overview of the field and are available in the library.

  1. N.-T. Nguyen and S. T. Wereley, Fundamentals and Applications of Microfluidics, Artech House, Boston, MA, 2002.
  2. G. Karniadakis and A. Beskok, Micro Flows: Fundamentals and Simulations, Springer-Verlag, 2001.
  3. J. Cheng and L. K. Kricka, Biochip Technology, Taylor & Francis, 2001.
  4. A. Manz and H. Becker, Microsystem Technology in Chemistry and Life Science, Springer-Verlag, 1998.
  5. M. Madou, Fundamentals of Microfabrication, 2nd ed., CRC, 2002.
  6. G. T. A. Kovacs, Micromachined Transducers Sourcebook, McGraw Hill, 1998.


The final course grade comprises:

Lab Reports 20%
Presentations 30%
Final Report 30%
Class Participation 10%
Homework 10%

Final grades will be assigned based on the following scale:

Percentage Letter
>=97 A+
96–93 A
92–90 A-
89–87 B+
86–83 B
82–80 B-
79–77 C+
76–73 C
72–70 C-
69–67 D+
66–63 D
62–60 D-
<60 F


Lab Reports: Succinct lab reports will be due before the start of the following week’s lab.

Final Report: Each student will prepare a final 10 page report on their design and findings. Report guidelines will be forthcoming. The report will be due during finals week.

Presentation: Each student will prepare and give a 15 min presentation describing their design and findings. The presentations will take place during finals week. Additionally, throughout the semester, each student will give short 5–10 minute presentations on their progress, troubles, and successes to develop presentation skills and address any issues.

Course Schedule

No. Date Topic Lab Handouts
1 Aug 17 Introduction Purcell
2 Aug 22 Microfluidics applications Slides
3 Aug 24 Fluid mechanics Brody
4 Aug 29 Fluid mechanics cont’d Slides
5 Aug 31 Fluid mechanics cont’d Slides
6 Sep 5 Microfluidic mixers Slides
Mixing Notes
7 Sep 7 Modeling I 1 - COMSOL Modeling I Student Notes
Modeling Chapter(s)
8 Sep 12 Modeling II 2 - COMSOL Modeling I
9 Sep 14 Modeling III
10 Sep 19 Device Modeling I 3 - Device Modeling I
11 Sep 21 Device Modeling I cont’d
12 Sep 26 Device Modeling II 4 - Device Modeling II
13 Sep 28 Device Modeling II cont’d
14 Oct 3 Device Modeling III No lab (Fall Break)
Oct 5 Fall Break
15 Oct 10 Device Modeling III cont’d 5 - Device Modeling III
16 Oct 12 Device Modeling III cont’d
17 Oct 17 Mask Design 6 - Mask Design Slides
18 Oct 19 Mask Design cont’d
19 Oct 24 Fabrication I 7 - Fabrication I (SU-8) Slides
20 Oct 26 Fabrication I cont’d
21 Oct 31 Fabrication II 8 - Fabrication II (PDMS) Slides
22 Nov 2 Fabrication II cont’d
23 Nov 7 Characterization 9 - Device Characterization Slides
24 Nov 9 Characterization cont’d
25 Nov 14 Data Analysis 10 - Data Analysis Slides
Final Presentation
Final Report
Image Analysis
26 Nov 16 Data Analysis cont’d
27 Nov 21 Nanofluidics No lab (Thanksgiving)
Nov 23 Thanksgiving Break
28 Nov 28 Applications of BioMEMS 11 - Final Report
and Presentations
29 Nov 30 Presentations

NCSU Policies

Academic integrity

Students are expected to adhere to the guidelines for academic integrity outlined in the NCSU Code of Student Conduct. Cases of misconduct will be addressed according to the procedures outlined in the Code. Your signature on any submitted work implies that you have neither given nor received unauthorized aid.

Student disabilities

Reasonable accommodations will be made for students with verifiable disabilities. In order to take advantage of available accommodations, students must register with Disability Services for Students at 2221 Student Health Services Building, 2815 Cates Avenue, Campus Box 7509, 919-515-7653. For more information on NC State’s policy on working with students with disabilities, please see the Academic Accommodations for Students with Disabilities Regulation.


Students are expected to attend all classes. Read the NCSU attendance policy for definitions of excused absences. If you anticipate an excused absence on a due date, please see one of the instructors to make other arrangements.

Class evaluation

Online class evaluations will be available to students at classeval.

Non-discrimination statement

NC State University provides equality of opportunity in education and employment for all students and employees. Accordingly, NC State affirms its commitment to maintain a work environment for all employees and an academic environment for all students that is free from all forms of discrimination. Discrimination based on race, color, religion, creed, sex, national origin, age, disability, veteran status, or sexual orientation is a violation of state and federal law and/or NC State University policy and will not be tolerated. Harassment of any person (either in the form of quid pro quo or creation of a hostile environment) based on race, color, religion, creed, sex, national origin, age, disability, veteran status, or sexual orientation also is a violation of state and federal law and/or NC State University policy and will not be tolerated. Retaliation against any person who complains about discrimination is also prohibited. NC State’s policies and regulations covering discrimination, harassment, and retaliation may be accessed here and here. Any person who feels that he or she has been the subject of prohibited discrimination, harassment, or retaliation should contact the Office for Equal Opportunity (OEO).