BME 444 Biomedical Controls — Spring 2019

Lectures: 11:00–12:15 TR, Brevard Hall Room 122
Office: Glenn Walker, Brevard Hall Room 333,
Office hours: Drop in or check my calendar and email me for an appointment.
Teaching Assistant: Jomiloju “JJ” Adebolu

Required Text: Control Systems Engineering (7th Edition), Norman S. Nise, Wiley 2015.

Recommended Text: The Application of Control Theory to Physiological Systems, Howard T. Milhorn, Saunders 1966.

Course Objectives

By the end of the course, students will be able to:

General Information

If you have questions during reading, solving homework problems, writing up reports, studying for exams, etc., send me an email with the question. I will respond to all students, “A student asked the following question…” so you will not be identified. Office visits are also welcome.


Homework is due at the beginning of class on the due date.

Homework is assigned to help you practice applying the principles you learn in class. If you are late to class, so is the homework. Late homework will receive a maximum grade of 50%. After 24 hours, late HW will receive a grade of 0%.


Final Exam: Tuesday, May 7, 12:00–3:20 PM in Brevard 122.

Bring your own calculator to the exams—cell phones will not be allowed as a substitute. Check your batteries before the exam. Exams missed with certified medical excuses or prior instructor approval will be dealt with individually.


The final course grade comprises:

Homework 20%
Exams 45%
Final 35%

Final grades will be assigned based on the following scale:

Percentage Letter
>=93 A
92–90 A-
89–87 B+
86–83 B
82–80 B-
79–77 C+
76–73 C
72–70 C-
69–67 D+
66–63 D
62–60 D-
<60 F

Course Schedule

Lesson Date Topic HW Handouts
1 Jan 22 Intro to technological systems (N 1) HW1
Due Jan 29
2 Jan 24 LaPlace; G(s);
Electrical systems (N 2)
3 Jan 29 G(s) of mechanical systems (N 2) HW2
Due Feb 5
4 Jan 31 G(s) of mechanical systems (N 2)
5 Feb 05 State space (N 3) HW3
Due Feb 12
State Space
6 Feb 07 State space (N 3) Aquifer Problem
7 Feb 12 Intro to physiological systems (M 8) HW4
Due Feb 21
8 Feb 14 No class
9 Feb 19 Physiological system DE
(M 3)
Seat model
10 Feb 21 Time response (N 4) HW5
Due Feb 28
1st Order Response
11 Feb 26 Time response (N 4) Slides
12 Feb 28 Review IO Exam 1
13 Mar 05 Exam 1
14 Mar 07 Block diagrams (N 5)
Mar 12 Spring Break
Mar 14 Spring Break
15 Mar 19 Simplification; Signal flow (N 5) HW6
Due Mar 26
16 Mar 21 Stability (N 6) HW7
Due Mar 28
17 Mar 26 SS errors (N 7)
18 Mar 28 SS errors (N 7) HW8
Due Apr 2
19 Apr 02 Root locus (N 8) HW9
Due Apr 9
20 Apr 04 Frequency response (N 9)
21 Apr 09 Frequency response (N 9) tf and zpk
22 Apr 11 Frequency response (N 9) HW10
Due Apr 16
23 Apr 16 Review IO Exam 2
24 Apr 18 Exam 2
25 Apr 23 Example: Glucose control
26 Apr 25 Example: Glucose control
27 Apr 30 Example: Glucose control
28 May 02 Review IO Final Exam

(N = Nise, M = Milhorn)

University of Mississippi Policies

Academic integrity

Students are expected to adhere to the guidelines for academic integrity outlined in the University of Mississippi Policy for Academic Conduct and Discipline. Cases of misconduct will be addressed according to the procedures outlined in the Policy. Your signature on any submitted work implies that you have neither given nor received unauthorized aid.

Student disabilities

Reasonable accommodations will be made for students with verifiable disabilities. In order to take advantage of available accommodations, students must register with the Office of Student Disability Services at 234 Martindale, 662-915-7128.


Students are expected to attend all classes. Read the Credits and Grades Policy (ACA.AR.200.003) and the Guidelines for Class Attendance Policies (ACA.AR.200.004) for more information. If you anticipate an excused absence on a due date, please notify me so that we can agree on an alternate due date.

Non-discrimination statement

The University of Mississippi provides equality of opportunity in education and employment for all students and employees. Accordingly, the University of Mississippi affirms its commitment to maintain a work environment for all employees and an academic environment for all students that is free from all forms of discrimination. Discrimination based on race, color, religion, creed, sex, national origin, age, disability, veteran status, or sexual orientation is a violation of state and federal law and/or University of Mississippi policy and will not be tolerated. Harassment of any person (either in the form of quid pro quo or creation of a hostile environment) based on race, color, religion, creed, sex, national origin, age, disability, veteran status, or sexual orientation also is a violation of state and federal law and/or University of Mississippi policy and will not be tolerated. Retaliation against any person who complains about discrimination is also prohibited. The University of Mississippi’s policies and regulations covering discrimination, harassment, and retaliation may be accessed here. Any person who feels that he or she has been the subject of prohibited discrimination, harassment, or retaliation should contact the Office of Equal Opportunity and Regulatory Compliance (EORC) or the Title IX Coordinator.